Metabolic & weight · Peptide
Tirzepatide
Also known as Mounjaro, Zepbound
A dual GLP-1 + GIP hormone mimic — currently the most effective approved weight-loss peptide.
Status as of 2026-07 · reclassification ≠ FDA approval · educational only, not medical advice.
The signal it sends
Hits two gut-hormone receptors at once (GLP-1 + GIP), amplifying appetite and glucose control.
Benefits & effects studied
- Up to ~21% weight loss in trials
- Best-in-class glucose control
- Improves blood pressure & lipids
Research state
Robust Phase III (SURMOUNT/SURPASS); approved for diabetes & obesity.
Dosing & pharmacokinetics
Weekly subcutaneous injection, titrated. Half-life: ~5 days (once-weekly).
Dosing information is educational only. Tirzepatide decisions belong with a licensed clinician — Jevity does not recommend or supply dosing.
History & discovery
First described late 2010s by Eli Lilly Origin: Engineered by Eli Lilly by building GLP-1 activity into the native GIP peptide sequence, creating a dual 'twincretin' to exploit the synergistic insulin response of GIP and GLP-1 together; approved by the FDA as Mounjaro in May 2022..
Molecular structure
A synthetic linear 39-amino-acid peptide based on the GIP sequence, acylated with a fatty-acid chain for albumin binding and once-weekly dosing.
Frequently asked questions
Is Tirzepatide FDA-approved?
FDA-approved (Mounjaro®, Zepbound®) On Jevity's evidence scale, Tirzepatide is graded "FDA-approved". Reclassification for compounding is not the same as FDA approval.
What is Tirzepatide used for?
A dual GLP-1 + GIP hormone mimic — currently the most effective approved weight-loss peptide. Hits two gut-hormone receptors at once (GLP-1 + GIP), amplifying appetite and glucose control. Studied effects include: Up to ~21% weight loss in trials; Best-in-class glucose control; Improves blood pressure & lipids. This is educational information, not a recommendation to use it.
Is Tirzepatide legal in the UAE?
UAE / DHA status: Prescription medicine — DHA-licensed provider
Is Tirzepatide banned in sport?
WADA status: Not prohibited
What is Tirzepatide's Jevity Score?
Tirzepatide has a Jevity Score of 100/100 — a proprietary composite of evidence strength (10/10), regulatory clarity (10/10) and supply verifiability (10/10). It reflects how established and legitimate the compound is, not a recommendation.
Related metabolic & weight peptides
Educational information only — not medical advice, a diagnosis, or a recommendation to use any substance or therapy. Regulatory status changes; verify current rules and any personal decision with a licensed clinician. Jevity is operated by Upcapital Global FZCO, Dubai, UAE.