Skin & cosmetic · Peptide
Argireline
Also known as Acetyl Hexapeptide-8
A topical 'Botox-like' peptide that softens expression lines.
Status as of 2026-07 · reclassification ≠ FDA approval · educational only, not medical advice.
The signal it sends
Mildly reduces release of signals that make facial muscles contract.
Benefits & effects studied
- Softer expression lines
- Smoother surface
Research state
Modest topical evidence; effects gradual.
Dosing & pharmacokinetics
Topical, once or twice daily. Half-life: n/a (topical).
Dosing information is educational only. Argireline decisions belong with a licensed clinician — Jevity does not recommend or supply dosing.
History & discovery
First described 2002 by Lipotec (now Lubrizol), Spain Origin: Developed by the Spanish lab Lipotec as a topical 'Botox-like' anti-wrinkle cosmetic peptide; discovered to mimic part of the SNARE complex protein SNAP-25, destabilizing it to reduce neurotransmitter release and muscle contraction..
Molecular structure
A synthetic six-amino-acid peptide (acetyl hexapeptide-8, formerly -3) that is a fragment mimic of the SNAP-25 protein.
Frequently asked questions
Is Argireline FDA-approved?
Cosmetic ingredient (topical) On Jevity's evidence scale, Argireline is graded "Topical cosmetic". Reclassification for compounding is not the same as FDA approval.
What is Argireline used for?
A topical 'Botox-like' peptide that softens expression lines. Mildly reduces release of signals that make facial muscles contract. Studied effects include: Softer expression lines; Smoother surface. This is educational information, not a recommendation to use it.
Is Argireline legal in the UAE?
UAE / DHA status: Available as a cosmetic (topical)
Is Argireline banned in sport?
WADA status: Not prohibited
What is Argireline's Jevity Score?
Argireline has a Jevity Score of 63/100 — a proprietary composite of evidence strength (5/10), regulatory clarity (8/10) and supply verifiability (7/10). It reflects how established and legitimate the compound is, not a recommendation.
Related skin & cosmetic peptides
Educational information only — not medical advice, a diagnosis, or a recommendation to use any substance or therapy. Regulatory status changes; verify current rules and any personal decision with a licensed clinician. Jevity is operated by Upcapital Global FZCO, Dubai, UAE.