Sexual & hormonal · Peptide
PT-141
Also known as Bremelanotide, Vyleesi
Acts in the brain to support sexual desire and arousal.
Status as of 2026-07 · reclassification ≠ FDA approval · educational only, not medical advice.
The signal it sends
Activates central melanocortin receptors (a brain route, not the vascular route of Viagra).
Benefits & effects studied
- Supports libido & arousal
- Approved for some low-desire in women
Research state
Approved (Vyleesi) for HSDD in premenopausal women.
Dosing & pharmacokinetics
As-needed subcutaneous injection before activity. Half-life: ~2.7 hours.
Dosing information is educational only. PT-141 decisions belong with a licensed clinician — Jevity does not recommend or supply dosing.
History & discovery
First described early 2000s by Palatin Technologies (based on University of Arizona / Victor Hruby melanocortin work) Origin: Refined by Palatin Technologies in the early 2000s from Melanotan II, a melanocortin analog originally developed at the University of Arizona as a sunless tanning agent; researchers noticed unexpected effects on sexual arousal and isolated that activity into PT-141. Approved as Vyleesi in 2019..
Molecular structure
A cyclic seven-amino-acid peptide (heptapeptide) melanocortin receptor agonist, derived from Melanotan II / alpha-MSH.
Frequently asked questions
Is PT-141 FDA-approved?
FDA-approved (Vyleesi®) On Jevity's evidence scale, PT-141 is graded "FDA-approved". Reclassification for compounding is not the same as FDA approval.
What is PT-141 used for?
Acts in the brain to support sexual desire and arousal. Activates central melanocortin receptors (a brain route, not the vascular route of Viagra). Studied effects include: Supports libido & arousal; Approved for some low-desire in women. This is educational information, not a recommendation to use it.
Is PT-141 legal in the UAE?
UAE / DHA status: Prescription medicine — DHA-licensed provider
Is PT-141 banned in sport?
WADA status: Not prohibited
What is PT-141's Jevity Score?
PT-141 has a Jevity Score of 93/100 — a proprietary composite of evidence strength (10/10), regulatory clarity (9/10) and supply verifiability (8/10). It reflects how established and legitimate the compound is, not a recommendation.
Related sexual & hormonal peptides
Educational information only — not medical advice, a diagnosis, or a recommendation to use any substance or therapy. Regulatory status changes; verify current rules and any personal decision with a licensed clinician. Jevity is operated by Upcapital Global FZCO, Dubai, UAE.