Longevity & cellular · Peptide
Elamipretide
Also known as SS-31, MTP-131
A mitochondria-targeting peptide studied for energy-failing tissues and rare diseases.
Status as of 2026-07 · reclassification ≠ FDA approval · educational only, not medical advice.
The signal it sends
Binds cardiolipin in mitochondria to stabilize energy production and reduce oxidative stress.
Benefits & effects studied
- Mitochondrial-function research
- Heart & muscle disease trials
Research state
Multiple human trials (mixed results); not yet broadly approved.
Dosing & pharmacokinetics
Daily subcutaneous in trials. Half-life: ~2 hours.
Dosing information is educational only. Elamipretide decisions belong with a licensed clinician — Jevity does not recommend or supply dosing.
History & discovery
First described early 2000s by Hazel H. Szeto and Peter W. Schiller Origin: Discovered fortuitously by Hazel Szeto and Peter Schiller during opioid-receptor studies; they refined the 'SS peptide' series (SS-02 to SS-20 to SS-31) to retain mitochondrial-targeting antioxidant properties while removing opioid affinity. Stealth BioTherapeutics licensed the IP in 2006..
Molecular structure
A cell-permeable tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that targets the mitochondrial inner membrane by binding cardiolipin.
Frequently asked questions
Is Elamipretide FDA-approved?
Investigational — late-stage trials (not approved) On Jevity's evidence scale, Elamipretide is graded "In human trials". Reclassification for compounding is not the same as FDA approval.
What is Elamipretide used for?
A mitochondria-targeting peptide studied for energy-failing tissues and rare diseases. Binds cardiolipin in mitochondria to stabilize energy production and reduce oxidative stress. Studied effects include: Mitochondrial-function research; Heart & muscle disease trials. This is educational information, not a recommendation to use it.
Is Elamipretide legal in the UAE?
UAE / DHA status: Not available — investigational
Is Elamipretide banned in sport?
WADA status: Verify on current WADA list
What is Elamipretide's Jevity Score?
Elamipretide has a Jevity Score of 58/100 — a proprietary composite of evidence strength (7/10), regulatory clarity (5/10) and supply verifiability (4/10). It reflects how established and legitimate the compound is, not a recommendation.
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Educational information only — not medical advice, a diagnosis, or a recommendation to use any substance or therapy. Regulatory status changes; verify current rules and any personal decision with a licensed clinician. Jevity is operated by Upcapital Global FZCO, Dubai, UAE.