Skin & cosmetic · Peptide
Matrixyl
Also known as Palmitoyl Pentapeptide-4
A well-studied topical peptide that signals skin to rebuild collagen.
Status as of 2026-07 · reclassification ≠ FDA approval · educational only, not medical advice.
The signal it sends
Mimics a collagen-breakdown fragment, prompting fibroblasts to make fresh collagen.
Benefits & effects studied
- Reduced wrinkle depth
- Improved firmness
- Pairs with retinoids & vitamin C
Research state
Among the better-evidenced cosmetic peptides.
Dosing & pharmacokinetics
Topical, once or twice daily. Half-life: n/a (topical).
Dosing information is educational only. Matrixyl decisions belong with a licensed clinician — Jevity does not recommend or supply dosing.
History & discovery
First described 2000 by Karl Lintner (Sederma) Origin: Discovered by Karl Lintner at Sederma, inspired by research on collagen-stimulating peptides; he attached a palmitic-acid chain to a procollagen fragment to enable skin penetration, and Sederma launched it commercially as Matrixyl in 2000..
Molecular structure
A synthetic signal peptide consisting of the sequence KTTKS (a procollagen fragment) conjugated to palmitic acid (palmitoyl pentapeptide-4 / pal-KTTKS).
Frequently asked questions
Is Matrixyl FDA-approved?
Cosmetic ingredient (topical) On Jevity's evidence scale, Matrixyl is graded "Topical cosmetic". Reclassification for compounding is not the same as FDA approval.
What is Matrixyl used for?
A well-studied topical peptide that signals skin to rebuild collagen. Mimics a collagen-breakdown fragment, prompting fibroblasts to make fresh collagen. Studied effects include: Reduced wrinkle depth; Improved firmness; Pairs with retinoids & vitamin C. This is educational information, not a recommendation to use it.
Is Matrixyl legal in the UAE?
UAE / DHA status: Available as a cosmetic (topical)
Is Matrixyl banned in sport?
WADA status: Not prohibited
What is Matrixyl's Jevity Score?
Matrixyl has a Jevity Score of 63/100 — a proprietary composite of evidence strength (5/10), regulatory clarity (8/10) and supply verifiability (7/10). It reflects how established and legitimate the compound is, not a recommendation.
Related skin & cosmetic peptides
Educational information only — not medical advice, a diagnosis, or a recommendation to use any substance or therapy. Regulatory status changes; verify current rules and any personal decision with a licensed clinician. Jevity is operated by Upcapital Global FZCO, Dubai, UAE.