Regenerative therapy
Does NAD⁺ / NMN precursors work?
NMN, NR, IV NAD+
Early / mixed evidence
Reliably raises NAD⁺ and is well-tolerated — but benefits are on surrogate markers.
What it is
NAD⁺ is a coenzyme central to cellular energy that declines with age. NMN and NR are precursors taken to raise it.
The evidence
Human trials consistently show NMN/NR raise blood NAD⁺ and are well-tolerated; a meta-analysis (~412 participants) found signals for gait speed, insulin sensitivity, and liver enzymes.
The honest reality
It's not established that raising blood NAD⁺ repletes tissue NAD⁺ or modifies disease risk/lifespan in healthy people — effects are on surrogate markers. FDA excluded NMN as a supplement in 2022, then reversed in Sept 2025.
Regulatory status
NMN is legal again as a US dietary supplement (Sept 2025); NR is a supplement. IV NAD⁺ is compounded/off-label. UAE: sold as supplements; IV drips via licensed clinics.
Frequently asked questions
Does NAD⁺ / NMN precursors work for anti-aging?
Reliably raises NAD⁺ and is well-tolerated — but benefits are on surrogate markers. Human trials consistently show NMN/NR raise blood NAD⁺ and are well-tolerated; a meta-analysis (~412 participants) found signals for gait speed, insulin sensitivity, and liver enzymes.
Is NAD⁺ / NMN precursors FDA-approved or safe?
NMN is legal again as a US dietary supplement (Sept 2025); NR is a supplement. IV NAD⁺ is compounded/off-label. UAE: sold as supplements; IV drips via licensed clinics. It's not established that raising blood NAD⁺ repletes tissue NAD⁺ or modifies disease risk/lifespan in healthy people — effects are on surrogate markers. FDA excluded NMN as a supplement in 2022, then reversed in Sept 2025.
Should I try NAD⁺ / NMN precursors?
Jevity grades NAD⁺ / NMN precursors as "Early / mixed evidence". It's not established that raising blood NAD⁺ repletes tissue NAD⁺ or modifies disease risk/lifespan in healthy people — effects are on surrogate markers. FDA excluded NMN as a supplement in 2022, then reversed in Sept 2025. Any decision belongs with a licensed clinician — this is educational information, not medical advice.
Sources
Educational information only — not medical advice, a diagnosis, or a recommendation to use any substance or therapy. Regulatory status changes; verify current rules and any personal decision with a licensed clinician. Jevity is operated by Upcapital Global FZCO, Dubai, UAE.